MSE Colloquium and Undergraduate Poster Symposium - Fri, Aug 26 at 3:30PM

MSE Undergraduate Research Program Invited Talk

Friday, August 26, 2011
Paul G. Allen Auditorium (CIS-X 101)
Lecture at 3:30PM

Bioinspired Soft Materials to Direct Stem Cell Function and Tissue Regeneration

Kevin E. Healy

Jan Fandrianto Distinguished Professor in Engineering

Departments of Materials Science and Engineering, and Bioengineering

University of California at Berkeley

 

Highly regulated signals in the stem cell microenvironment, such as growth factor presentation and concentration, matrix stiffness, and ligand adhesion density have been implicated in modulating stem cell proliferation and maturation. Therefore, it is desirable to have independent control over both the biochemical and mechanical cues presented to cells to analyze their relative and combined effects on stem cell function. Accordingly, we have developed synthetic hydrogels and biointerfaces to assess the effects of adhesion ligand presentation and material moduli spanning physiologically relevant ranges (10 to 10,000 Pa) on stem cell function. Employing these soft materials, we have demonstrated that the mechanical and biochemical properties of a stem cell microenvironment can be tuned to regulate the self-renewal and differentiation of different types of stem cells including human embryonic, neural, and mesenchymal stem cells. We have further modified these tunable biomimetic hydrogels with matrix metalloproteinase labile crosslinkers (e.g. MMP-2, 9 &13), to be used as an assistive microenvironment for transplantation of stem cells into diseased or damaged tissue such as the infracted myocardium. These biomimetic hydrogels provide a foundation for systematic development of "pro-survival" microenvironments for cell transplantation and the potential improvement in the long-term results of regenerative therapies. Various examples from our work will be discussed during this presentation.

 

­­­MSE Undergraduate Summer Research Poster Symposium
Science and Technology at the Nanoscale

Friday, August 26, 2011

CIS-X Patio
4:30PM

After the invited talk by Prof. Kevin Healy

Sponsored by the  Office of the Vice Provost for Undergraduate Education (VPUE)

* Pizza and drinks will be served*

#	Student Name	Advisor	Project Name
1	Dustin Barfield	N. Melosh	Photon-enhanced Thermionic Emission
2	Jena Barnes	R. Sinclair	FIB and SEM of Nanomaterials
3	Sy Bohy	A. Salleo	Transparent Electrodes and Applications for Al and Ga Doped Zinc Oxide Nanowires
4	Mai Bui	R. Dauskardt	Effect of Sunscreen on UV Damage of Human Stratum Corneum
5	Thomas Carney	Y. Cui	Surface Engineering of SnO Nanofibers for High Capacity Lithium Ion Batteries
6	Alice Che	M. McGehee	Effect of Using Chlorinated ITO for Polymer Solar Cells
7	Kevin Chow	A. Salleo	Ultraviolet Curing Process for Indium Oxide Thin-Film Transistors
8	Ben Cohn	S. Doniach	Simulation of Local-Ordered Glasses to Practice Intensity Correlation Techniques
9	Jo-Ann Deasis	R. Dauskardt	Mechanical Behavior of Macroporous Hybrid Organic-Inorganic Thin Films
10	Justin Doanne	J. Dionne	The Path to Plasmon-Enhanced Upconversion Using Ag Nanoprisms
11	Nick Hartley	A. Lindenberg	Examining Ultrashort Laser Pulses and Photon Emission at Plasma Filament Intersections
12	Olivia Isaac	N. Melosh	Electroporation to Improve Nanostraw Penetration in Cells
13	Pao Jirakulpattana	M. McGehee	Organic Solar Cells
14	Kyle Johnson	S. Heilshorn	Diffusion Characterization of RGD Elastin Hydrogels
15	Zoe Kaufman	P. McIntyre	Annealing Effects on Nano-Structured Ir/TiO2/Si/Al Anode Efficiency
16	Kendrick Kho	W. Nix	Size Dependence of the Mechanical Properties of hcp Zinc Nanopillars
17	Maxwell Kim	S. Heilshorn	Designing a Protein-Engineered, Nanofibrous Scaffold for Tissue Engineering
18	Richard Lee	M. Brongersma	Investigating Si Nanowires for Solar-Driven Water Splitting
19	Janina Motter	B. Cui	Upconversion Nanoparticles for Biological Applications
20	Eric Newton	P. McIntyre	Electrochem. Cell for Photo-Illumination of Nanostructured Anodes for H2O Oxidation
21	Karina Padilla	S. Heilshorn	Biotemplating of 2D and 3D Nanostructures
22	Dieter Rutzen	S. Wang	Magnetic Separation with a Microfabricated Magnetic Sifter
23	Jacob Sander	R. Sinclair	FIB and SEM of Nanomaterials
24	Jacob Smith	S. Wang	Optimization of TiO2 Synthesis for Magnetic Nanoparticle Application
25	Arianna Wee	R. Sinclair	Characterizing Gold Nanoparticles in Macrophages

Chris Earhart

Acting Assistant Professor
Materials Science & Engineering
Stanford University
496 Lomita Mall, Durand Building, Rm #131
Stanford, CA 94305-4034
Phone: 650-723-1284