Jose I. Padovani
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Flexible 4,096-Pixel Multi-Electrode Arrays of Electrodes, CMOS and Image
Sensors: a tool for interfacing retinal circuitry and a basis for retinal
prosthesis
Long-Sheng Fan
National Tsing Hua University/Univ. California, Berkeley
Abstract
To achieve localized retinal neural stimulation with high granularity over
reasonable field of view within power constraints, we integrated a flexible
4,096-element retina chip 30 mm in thickness using a flexible 180nm CMOS
Image Sensor (CIS) technology. The retina chip is 3x3 mm in size (including
multiplexing electronics for pixel characterizations) with an array of 10 mm
electrodes and photo sensors 30 mm in pitch. The flexible format allows
better proximity between electrodes and retina neurons for localized
stimulation, and the integrated local electronics allows supplying
individual electrode the adequate and appropriate stimulation waveforms
right next to each individual electrodes. The chip senses local light
intensity and generates corresponding biphasic current at each pixel. Images
are projected onto the chip and corresponding biphasic currents for
stimulating retina tissue from each pixel are mapped. Loose patch and
whole-cell patch clamp techniques in vitro are used to characterize the
mouse retinal ganglion cells responses on these arrays with bipolar cells
facing down. With local active devices and signal processing capability, it
could also potentially be an enabling tool to interface retinal neurons to
the individual cell level for studying retinal neural network.
Biography
Long‑Sheng Fan received his MS & Ph.D. degrees in Electrical Engineering
and Computer Sciences both from the University of California at Berkeley. He
joined IBM Almaden Research Center as a Research Staff Member working on
magnetic sensors, AFM recording and he was an original advocator for
dual-stage servo in magnetic drives and demonstrated a magnetic recording
servo track density beyond 50kTPI using a multilevel metal MEMS
microactuator technology, which was transferred to an IBM pilot line. He
has served as a section editor for Sensors and Actuators (1994‑1997), a
government consultant and a member of proposal review panel of NSF and NIH,
and he is the IEEE Technical Program Vice Chair of Transducers 2009 and
designated Technical Program Chair of IEEE Transducers 2011. Dr. Fan joined
National Tsing-Hua University as a Tsing-Hua Professor and the Director of
the Institute of Nano Engineering and MicroSystems during 2003-9, and he was
the coordinator of Heterogeneous Integration Program of the SoC National
Program in Taiwan, promoting MEMS IP reuse with standard process modules &
EDA for MEMS/IC co-design. He is an IEEE Fellow and currently a Visiting
Professor in EECS, UCB. His academic research interest is in the biomedical
microsystems for medical implants & MEMS-enabled medical instruments.
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