Tuesday, February 28, 2012

Mathematica

Hi All

Can anyone help me for Mathematica issue?

I'm now working on some numerical calculations with multiple integrations and fitting to data points but I can't figure out the error message.

Thanks,

Boram

Han-Bo-Ram Lee, Ph.D
Bent Research Group
Department of Chemical Engineering
Stanford University

Mail : Rm 113, Stauffer III Bldg., 381 North South Mall, Stanford, CA 94305
Email : sixram[at]stanford.edu or sixram[at]gmail.com
WWW : bentgroup.stanford.edu/


RE: Thursday, March 1: Lunch discussion with Dr. Giacomo Vacca, RSVP requested

Thank you for your interest in the lunch event.  All available spots have now been filled.

 

From: Ross Audet [mailto:audet@stanford.edu]
Sent: Tuesday, February 28, 2012 11:33 AM
To: 'studentosa@lists.stanford.edu'; 'gl-res-assts@lists.Stanford.EDU'; 'gl-postdocs@lists.Stanford.EDU'; 'labmembers@snf.stanford.edu'
Subject: Thursday, March 1: Lunch discussion with Dr. Giacomo Vacca, RSVP requested

 

There are still a few spots available for the lunch discussion on Thursday!

 

Lunch discussion with Dr. Giacomo Vacca of Kinetic River Corp.

Presented by the Stanford Photonics Research Center and the Stanford Optical Society

 

Thursday, March 1, 2012

12 PM - 1 PM

Nano 317

 

Space is limited.  RSVP to stanford-photons@stanford.edu.

Lunch will be provided to participants.

 

Join us for an informal lunch discussion with Dr. Giacomo Vacca of Kinetic River Corp., a technical consulting company focusing on optics in a range of industries including medicine and the life sciences. Dr. Vacca will discuss career opportunities in industry for PhDs in optics and photonics, drawing on his experiences in positions in R&D, marketing, and business development in both startups and large companies. Additionally, he will discuss opportunities for scientists as independent consultants.

 

Biography:

Giacomo Vacca earned his B.A. and M.A. in Physics from Harvard University, and his Ph.D. in Applied Physics from Stanford University. His dissertation, under the guidance of Nobel Prize winner Bob Laughlin, introduced a new ultrafast optical technique for investigating microscopic fluid phenomena. From 2000 to 2005 he worked in R&D and Marketing for two Silicon Valley optics startups. In 2005 he was recruited by Abbott Labs to lead their hematology research group in Santa Clara. There he developed a breakthrough cellular analysis technology, for which he received a Platinum Research Award.  His most recent honors are having been elected to Senior Member of the Optical Society of America and to Research Fellow of the Volwiler Society at Abbott Laboratories. In 2010 he founded Kinetic River, a medical and life-science technology company providing consulting services and developing disruptive diagnostics and research products. He has been awarded 5 patents and has 19 more pending. 

 

To learn more about the Stanford Optical Society, visit http://photons.stanford.edu

 

seminar at 4:00, Allen 101X Peter Krulevitch J&J


Innovation Within a Large Medical Device Company:
a Journey from Microtechnology R&D to User Needs Driven Design

Dr. Peter Krulevitch
Research Fellow, Janssen R&D

Abstract:

Over the past ten years, the R&D environment inside large medical device companies has changed considerably, making it increasingly challenging to develop innovative products from within. Spending on early development projects has declined, including an end to funding for projects not directly tied to product launches. At the same time, the allowable time before R&D innovations must impact sales has decreased. As a result, the model for driving internal innovation has evolved. This presentation will cover one engineer’s R&D experience at Johnson & Johnson over a period of nearly ten years. Initial efforts focused on the application of microtechnology to medical devices, including Nitinol thin films aimed at cardiovascular applications and electrokinetic patch pumps for drug delivery.  Mid-term projects applied low risk microtechnology with increased attention to user needs, emphasis on industrial design as well as technology, and focus and accountability for near term results. Projects included insulin infusion sets and subcutaneous sensor inserters with flexible etched Nitinol/polymer hybrid needles, injection molded micropumps with etched valves for drug delivery, and drug delivery management systems. Recently, efforts have drifted away from technology-based innovation in favor of patient-centric design-based innovation, focusing on simple, intuitive to use devices. An example of a self-administration device for subcutaneous injections will be presented.

 

Short Bio:

Peter Krulevitch is a Research Fellow at Janssen R&D, the pharmaceutical development organization within Johnson & Johnson, where he leads a small team responsible for early development of devices for subcutaneous, intramuscular, intravenous, intranasal, and pulmonary delivery of large and small molecule drugs. He joined Janssen from J&J’s device sector, where he led a group focused on applying microtechnology to medical devices, and worked with LifeScan and Animas on devices for the treatment of diabetes. Prior to J&J, he was a Research Engineer at Lawrence Livermore National Laboratory’s Center for Microtechnology, where he worked on microfluidic systems for cell-based diagnostics and flexible electrode arrays for retinal implants, among other projects. He received his Ph.D. in Mechanical Engineering from UC Berkeley (1994), where he studied the mechanical properties of polycrystalline silicon at the Berkeley Sensor & Actuator Center with Professors Roger Howe and George Johnson. Dr. Krulevitch is co-inventor on approximately 50 issued patents.

Thursday, March 1: Lunch discussion with Dr. Giacomo Vacca, RSVP requested

There are still a few spots available for the lunch discussion on Thursday!

 

Lunch discussion with Dr. Giacomo Vacca of Kinetic River Corp.

Presented by the Stanford Photonics Research Center and the Stanford Optical Society

 

Thursday, March 1, 2012

12 PM - 1 PM

Nano 317

 

Space is limited.  RSVP to stanford-photons@stanford.edu.

Lunch will be provided to participants.

 

Join us for an informal lunch discussion with Dr. Giacomo Vacca of Kinetic River Corp., a technical consulting company focusing on optics in a range of industries including medicine and the life sciences. Dr. Vacca will discuss career opportunities in industry for PhDs in optics and photonics, drawing on his experiences in positions in R&D, marketing, and business development in both startups and large companies. Additionally, he will discuss opportunities for scientists as independent consultants.

 

Biography:

Giacomo Vacca earned his B.A. and M.A. in Physics from Harvard University, and his Ph.D. in Applied Physics from Stanford University. His dissertation, under the guidance of Nobel Prize winner Bob Laughlin, introduced a new ultrafast optical technique for investigating microscopic fluid phenomena. From 2000 to 2005 he worked in R&D and Marketing for two Silicon Valley optics startups. In 2005 he was recruited by Abbott Labs to lead their hematology research group in Santa Clara. There he developed a breakthrough cellular analysis technology, for which he received a Platinum Research Award.  His most recent honors are having been elected to Senior Member of the Optical Society of America and to Research Fellow of the Volwiler Society at Abbott Laboratories. In 2010 he founded Kinetic River, a medical and life-science technology company providing consulting services and developing disruptive diagnostics and research products. He has been awarded 5 patents and has 19 more pending. 

 

To learn more about the Stanford Optical Society, visit http://photons.stanford.edu

 

Can anyone sell me a fused silica/glass wafer of 0.6-0.7mm thickness?

Hi,

I need one or two Pyrex or fused silica wafers for an experiment. The
thickness should be from 600um to 700um preferably, and double side
polished. Thank you for your attention.

Ben

No Steam ( Cogen)

Hello all,

We have been informed that Cogen ( steam ) is down.

You might start seeing shift in the focus with regard to the exposure time.
Critical work should wait Non critical could continue, please do a
test wafer.
we will update you as soon as we have more information.

mahnaz

Monday, February 27, 2012

Pamela Bhatti seminar ... NOW in Clark Aud.

MEMS-based Approaches to Overcoming Sensory Loss in the Auditory and Vestibular Systems

Presented by:

Prof. Pamela T. Bhatti
School of Electrical and Computer Engineering, Georgia Institute of Technology

Monday, February 27, 2012
Clark Center Auditorium
4:00 PM

Abstract:
In the BioSystems Interface Laboratory we develop novel sensing and stimulating systems to 
overcome sensory loss. To enhance sound perception with cochlear implants, we have 
developed advanced thin-film intracochlear electrode arrays. Moving to the vestibular system, 
we pursue both an implantable and non-implantable systems. Analogous to a cochlear implant, 
we are developing a vestibular prosthesis to convey head rotation cues to the vestibular system 
through electrical stimulation of vestibular nerve fibers to overcome debilitating bilateral 
vestibular hypofunction. Complementing our work in implantable systems, we have developed 
a head worn angular motion monitoring system to aid patients in completing vestibular 
rehabilitation exercises at home. By utilizing a user-friendly interface to the system we hope to 
facilitate the transfer of patient measures to a clinic between rehabilitation sessions.

Short Bio:
Dr. Pamela Bhatti is an Assistant Professor in the School of Electrical and Computer Engineering
at Georgia Tech in Atlanta, GA. She received a B.S. in Engineering Science (Bioengineering) from
the University of California, Berkeley in 1989, an M.S. in Electrical Engineering from the University
of Washington in 1993, and a Ph.D. in Electrical Engineering from the University of Michigan, Ann
Arbor in 2006 with an emphasis on Micro-electro Mechanical Systems (MEMS). Before completing
her Ph.D., she researched the detection of breast cancer with ultrasound imaging at the University
of Michigan’s Department of Radiology (1997-1999). Her industry experience includes embedded 
systems software development at Microware Corporation, Des Moines, IA (1996-1997), local 
operating network applications development and customer support at Motorola 
Semiconductor in Austin, TX (1994-1995), and research and fabrication of controlled-release 
drug delivery systems at Alza Corporation in Palo Alto, CA (1986-1990). Pamela received the 
NSF CAREER Award in 2011. Committed to translating technology to the clinical setting, she is a 
KL2 Scholar with the Atlanta Clinical and Translations Sciences Institute.




 

What do you think about the reproducibility of AFM?(Please forget the last email)

Hi all,

 

To avoid confusion on my last question I am resending a new one. Sorry for the spam.

 

I am doing modification to a polymeric substrate and I want to track the change of the depth of a cavity on it. It is 300-nm deep, 800-nm wide and the possible change in depth after modification is about several to several tens of nanometer. In another word, I want to tell if the cavity changes from 300-nm deep to 305-nm deep, or from 300-nm deep to 295-nm deep. I was wondering whether the AFM is capable to of telling this difference, as the modification would take several hours, or even longer time so I can not do the measurement in a single run.

 

I would really like to get suggestions from those who know AFM well. Could anyone tell me your idea on the reproducibility of AFM? Concerning the experiments at different time, are they reliable on telling the change of several nanometers on the measure scale of several hundreds of nanometers? Also, will it affect much if the measurement last several days or the cantilever is heavily used or replaced? Any response will be highly appreciated.

 

Thanks,

 

Kangning

 
 
 
2012-02-27

kangning

What do you think about the reproducibility of AFM?

Hi all,

 

I am doing modification to a surface and I want to track the change of the depth of some nano-cavities on polymeric substrate. They are typically 300-nm deep, 800-nm wide and the possible change in their depth after modification, which I am going to measure, is about several to several tens of nanometer. I was wondering whether the AFM is capable to of telling the difference, as the modification would take several hours, and during that time others could have used the AFM or changed the cantilever.

 

I would really like to get suggestions from those who know AFM well. Could anyone tell me your idea on the reproducibility of AFM? Concerning the experiments at different time, are they reliable on telling the change of several nanometers on the measure scale of several hundreds of nanometers? Also, will it affect much if the measurement last several days or the cantilever is heavily used or replaced? Any response will be highly appreciated.

 

Thanks,

 

Kangning

 
 
 
2012-02-27

kangning

Lab bins

Dear labmembers --

We appreciate your enthusiasm for coming back to work in the lab -- but
please do not occupy lab bins without prior assignment. There is a new
system for managing lab bins (described at the link below), with
priority given to those who have been consistently active in the lab
and/or are actively enabling equipment now. This is necessary in our
effort to try to ensure that bins are assigned to people who are
actually using the lab. Bins are being randomly assigned, so any
personal items that are in unassigned bins are subject to being removed
from the lab.

Please see Maureen Baran about getting a bin assignment (or a locker
assignment, for that matter.)


http://snf.stanford.edu/cgi-bin/ezmlm-cgi?msp:4920:abpgpkkobjflecfaclag

Thanks for your attention --

Mary

--
Mary X. Tang, Ph.D.
Stanford Nanofabrication Facility
Paul G. Allen Room 136, Mail Code 4070
Stanford, CA 94305
(650)723-9980
mtang@stanford.edu
http://snf.stanford.edu

Reminder: Pamela Bhatti (Georgia Tech), Seminar 4-5 TODAY, Clark Center Aud.

MEMS-based Approaches to Overcoming Sensory Loss in the Auditory and Vestibular Systems

Presented by:

Prof. Pamela T. Bhatti
School of Electrical and Computer Engineering, Georgia Institute of Technology

Monday, February 27, 2012
Clark Center Auditorium
4:00 PM

Abstract:
In the BioSystems Interface Laboratory we develop novel sensing and stimulating systems to 
overcome sensory loss. To enhance sound perception with cochlear implants, we have 
developed advanced thin-film intracochlear electrode arrays. Moving to the vestibular system, 
we pursue both an implantable and non-implantable systems. Analogous to a cochlear implant, 
we are developing a vestibular prosthesis to convey head rotation cues to the vestibular system 
through electrical stimulation of vestibular nerve fibers to overcome debilitating bilateral 
vestibular hypofunction. Complementing our work in implantable systems, we have developed 
a head worn angular motion monitoring system to aid patients in completing vestibular 
rehabilitation exercises at home. By utilizing a user-friendly interface to the system we hope to 
facilitate the transfer of patient measures to a clinic between rehabilitation sessions.

Short Bio:
Dr. Pamela Bhatti is an Assistant Professor in the School of Electrical and Computer Engineering
at Georgia Tech in Atlanta, GA. She received a B.S. in Engineering Science (Bioengineering) from
the University of California, Berkeley in 1989, an M.S. in Electrical Engineering from the University
of Washington in 1993, and a Ph.D. in Electrical Engineering from the University of Michigan, Ann
Arbor in 2006 with an emphasis on Micro-electro Mechanical Systems (MEMS). Before completing
her Ph.D., she researched the detection of breast cancer with ultrasound imaging at the University
of Michigan’s Department of Radiology (1997-1999). Her industry experience includes embedded 
systems software development at Microware Corporation, Des Moines, IA (1996-1997), local 
operating network applications development and customer support at Motorola 
Semiconductor in Austin, TX (1994-1995), and research and fabrication of controlled-release 
drug delivery systems at Alza Corporation in Palo Alto, CA (1986-1990). Pamela received the 
NSF CAREER Award in 2011. Committed to translating technology to the clinical setting, she is a 
KL2 Scholar with the Atlanta Clinical and Translations Sciences Institute.


Sunday, February 26, 2012

[Reminder] EE Ph.D. Oral Examination: Jae-Woong Jeong, Feb. 27 at 3:00 pm, CIS-X Auditorium

Stanford University Ph.D. Oral Examination – Department of Electrical Engineering

 

Title:

Design of Optical Microsystems:

Applications in Biomedical Imaging and Optical Communication

 

Speaker: Jae-Woong Jeong

Advisor: Professor Olav Solgaard

 

Date: Monday, February 27, 2012

Time: 3:00 pm (refreshments at 2:45 pm)

Location: Allen-X Auditorium (formerly CIS-X Auditorium) - Room 101

 

Abstract:

 

Scaling of optical systems can open up new opportunities for various applications by enabling what would not be possible on a larger scale. Such miniaturized optical systems can be achieved through optical MEMS (Micro-electro-mechanical systems) technology. This technology not only enables optical devices with high performance and high functionality, but also allows miniaturization, integration, and batch fabrication of optical systems, making them portable, reliable, and cost-effective. In this talk, I will present two novel optical microsystems for applications in biomedical imaging and optical communication.

 

    In the first part of my talk, I will introduce the 3-D MEMS scanning system for a miniature dual-axis confocal (DAC) microendoscope, which is an emerging biomedical imaging modality with high resolution, good tissue penetration, large field of view, and the ability to provide both reflectance and fluorescence contrast images. A pair of MEMS scanners (2-D lateral and 1-D vertical MEMS scanners) that are designed to achieve 3-D scanning in an endoscope-compatible imaging probe will be presented. In addition, front-side processing of the scanners that enables not only simple and cost-effective fabrication but also compact and robust structures will be described. Co-operation of a 2-D lateral scanner and a 1-D vertical scanner enables fast 3-D microscopy over a volume that measures 340μm X 236μm X 286μm. I will describe the principle of the all-MEMS-based 3-D scanning DAC microscopy that gives the functionality of OCT to a confocal microscope by producing real-time imaging along the axial direction of the microscope.


    In the second part of my talk, I will describe the design, fabrication, and characterization of a multi-functional tunable optical filter, which is a key element for dynamic wavelength provisioning in reconfigurable optical networks and communication systems. This filter can control both the center wavelength and the passband independently and continuously, using a MEMS spatial light modulator (SLM) that is implemented with gold-coated mirrors microassembled on a MEMS platform. The design of SLM with large displacement bi-directional combdrive actuators will be demonstrated. Also, MEMS platform technology that enables a compact chip size with large apertures and high-quality optical mirrors will be presented. To verify the performance of the filter, it has been tested as an amplified spontaneous emission (ASE) noise rejection filter in a 10Gb/s optical communication system. I will discuss the filtering performance in the optical system in terms of bit error rate improvement.


Saturday, February 25, 2012

Friday, February 24, 2012

Comment p5000etch SNF 2012-02-24 17:48:56: CH.B OXIDE Etch rates

Thermal Ox = 3530A/min
3612 PR = 1800A/min
Single crystal Si = 750A/min
Polysilicon = 1010A/min
Sel Ox : PR = 2.0 : 1

Re: Comment p5000etch SNF 2011-12-12 10:02:59: Ch.B is still available

not without CHF3.....

fluoropolymer pre-bonding etchant for teflong bonding

Dear Labmembers,

I was wondering if anyone had some fluoropolymer pre-bonding etchant to bond some Teflon tubing to other metallic parts. I just need a little bit as I'm using microtubing that does not necessitate much.

Thanks in advance,

Noureddine

Problem p5000etch SNF 2012-02-24 14:42:00: CHF3 MFC reads 0

During oxide qual! I was doing an EP run to verify etch rate. Stopped at 113secs.

new SNF logo

Dear Labmembers and Staff,

I've attached the new SNF logo, which was selected by a panel of 8
judges from the SNF staff from the many entries we received, which were
relabeled by Ann Guerra in a randomized way to allow us to make an
unbiased assessment.

The winner: Jose Padovani.

Thanks, everyone, for your work on the design and on the judging. Five
of the 8 judges voted for R1 as #1. We'll integrated it into the
updated SNF website asap.

Roger

Comment p5000etch SNF 2012-02-24 11:31:21: Cl2/BCl3 update

A new chlorine cylinder is due in Monday, 2/27. If all goes well, BCl3 should be available next week as well.

Thursday, February 23, 2012

Re: Problem p5000etch SNF 2012-02-23 13:59:20: He flow deviation error

Found the He valve supply was shutoff, opened He valve
supply and ran b oxide recipe on chamber b w/out problem.

Problem p5000etch SNF 2012-02-23 13:59:20: He flow deviation error

I was trying to run CH.B OXIDE for the qual.....

FYI: Construction work update today and tomorrow

Hi all --

Just to let you know... There will be some fire alarm testing today,
between 1:30 and 2 pm. Alarms may go off briefly, but not to worry,
this is testing related to the continued renovation project. There will
also be paint removal in the area next to the lab/receiving area this
afternoon and tomorrow. Strong odors are not expected (paint will be
removed by grinding and vacuuming), but there may be some non-routine
smells.

Thanks for your patience --

Your SNF staff

--
Mary X. Tang, Ph.D.
Stanford Nanofabrication Facility
Paul G. Allen Room 136, Mail Code 4070
Stanford, CA 94305
(650)723-9980
mtang@stanford.edu
http://snf.stanford.edu

Wednesday, February 22, 2012

Special Seminar: Dr. Peter Krulevitch, "Innovation Within a Large Medical Device Company: a Journey from Microtechnology R&D to User Needs Driven Design"

Special Seminar

 


Innovation Within a Large Medical Device Company: a Journey from Microtechnology R&D to User Needs Driven Design

Speaker:
Dr. Peter Krulevitch
Research Fellow, Janssen R&D 

Tuesday, February 28, 2012
Allen 101X Auditorium
4:00-5:00pm

Abstract:
Over the past ten years, the R&D environment inside large medical device companies has changed considerably, making it increasingly challenging to develop innovative products from within. Spending on early development projects has declined, including an end to funding for projects not directly tied to product launches. At the same time, the allowable time before R&D innovations must impact sales has decreased. As a result, the model for driving internal innovation has evolved. This presentation will cover one engineer's R&D experience at Johnson & Johnson over a period of nearly ten years. Initial efforts focused on the application of microtechnology to medical devices, including Nitinol thin films aimed at cardiovascular applications and electrokinetic patch pumps for drug delivery. Mid-­‐term projects applied low risk microtechnology with increased attention to user needs, emphasis on industrial design as well as technology, and focus and accountability for near term results. Projects included insulin infusion sets and subcutaneous sensor inserters with flexible etched Nitinol/polymer hybrid needles, injection molded micropumps with etched valves for drug delivery, and drug delivery management systems. Recently, efforts have drifted away from technology-­‐based innovation in favor of patient-­‐centric design-­‐based innovation, focusing on simple, intuitive to use devices. An example of a self-­‐administration device for subcutaneous injections will be presented. 

Short Bio:
Peter Krulevitch is a Research Fellow at Janssen R&D, the pharmaceutical development organization within Johnson & Johnson, where he leads a small team responsible for early development of devices for subcutaneous, intramuscular, intravenous, intranasal, and pulmonary delivery of large and small molecule drugs. He joined Janssen from J&J's device sector, where he led a group focused on applying microtechnology to medical devices, and worked with LifeScan and Animas on devices for the treatment of diabetes. Prior to J&J, he was a Research Engineer at Lawrence Livermore National Laboratory's Center for Microtechnology, where he worked on microfluidic systems for cell-based diagnostics and flexible electrode arrays for retinal implants, among other projects. He received his Ph.D. in Mechanical Engineering from UC Berkeley (1994), where he studied the mechanical properties of polycrystalline silicon at the Berkeley Sensor & Actuator Center with Professors Roger Howe and George Johnson. Dr. Krulevitch is co-inventor on approximately 50 issued patents. 

Re: Shutdown p5000etch SNF 2011-12-13 18:43:03: Schedule shutdown

Chamber B ready for qual..

Re: Comment p5000etch SNF 2012-02-15 17:26:31: Robot extension problem

Changed extension position cable and robot interface cable,
cycled wafers to all three chambers w/out problem..

microbeads

hi labmembers,
might any of you  carry some polysterene/glass beads that's around 500um in size that i may have? i just need 30 or so of them (they sell them in the pounds which means you have lots of them if you might have purchased some)
http://www.amazon.com/No-hole-Metallic-Transparent-Glass-Microbeads/dp/B003WSUEYO/ref=sr_1_5?ie=UTF8&qid=1329953932&sr=8-5

i'll buy the item by 5pm today so please neglect this email after 5pm. however, i know i'll get a 'you've won some microbeads!' email by then. :)

thanks!


--
Regards,
Sonny

----
Department of Applied physics, Stanford University
research group: http://snow.stanford.edu/index.html

626-216-4597


Course Announcement- E204: Research Ethics for Engineers & Scientists

Dear labmembers --

Have you ever wondered:

- How is authorship on a paper decided? Who gets to be first author?
What are the responsibilities of a contributors to jointly authored paper?
- Who should be included as an inventor on a patent?
- Is it OK to omit "bad" data points from an analysis?
- What can and should you do if you suspect data fraud?
- How should peer review be handled? How is it actually done?
- Are you responsible for anticipating the ways, good and bad, that your
research might be used? What are a researcher's specific
responsibilities to society?
- What are the responsibilities of mentors and mentees?
- What kinds of conflicts of interest are important to avoid?

Explore these issues and more, in E204, Research Ethics for Engineers
and Scientists, a course that examines the practical aspects of
ethics for researchers with lectures, discussions, guest speakers, and
real case studies. This course is 1-2 units and will be held Spring
term, on Thursdays, 2:15 PM - 4:05 PM. The course instructor is
Prof. Robert McGinn, Director of the Program in Science, Technology&
Society. Last year's course featured the following guest speakers:
- Prof. Malcolm Beasely, Applied Physics, who headed the Hendrik Schon
commission
- Katherine Ku, Director of the Office of Technology Licensing, on
the ethics of licensing
- Prof. Roger Howe, Electrical Engineering, on authorship, publication
and intellectual property

For more information, see the Bulletin or contact Prof. McGinn.

For those of you supported by NSF fellowships, this course satisfies the NSF
requirement for "Training in the responsible and ethical conduct of
research." (http://dor.stanford.edu/rcr.html)


--
Mary X. Tang, Ph.D.
Stanford Nanofabrication Facility
Paul G. Allen Room 136, Mail Code 4070
Stanford, CA 94305
(650)723-9980
mtang@stanford.edu
http://snf.stanford.edu

Fire alarm testing, Thursday 1:30-2 pm

Dear lab and building occupants --

Please be aware that there will be fire alarm testing tomorrow (Thursday) between 1:30 and 2 pm. This is to support some demolition work for the lab renovation but requires a "spot" check of the whole building. This testing will be brief and will happen intermittently. Thank you for your help in this process.

Your SNF Staff

--
Mary X. Tang, Ph.D.
Stanford Nanofabrication Facility
Paul G. Allen Room 136, Mail Code 4070
Stanford, CA 94305
(650)723-9980
mtang@stanford.edu
http://snf.stanford.edu

[Reminder] TODAY - Oral Exam - 2:15 pm in Allen 101x - A Vacuum Encapsulated Resonator for Humidity Measurement

University PhD Dissertation Defense

A Vacuum Encapsulated Resonator for Humidity Measurement

Robert Hennessy
Department of Electrical Engineering
Advisor: Prof. Roger T. Howe

Wednesday, February 22, 2012
2:15 pm (refreshments at  2 pm)
Paul G. Allen Auditorium (CIS-X 101)

http://cis.stanford.edu/directions/


Relative humidity sensing is important in many applications including home appliances, semiconductor manufacturing, air conditioning, medical, automotive and meteorological. Various technologies exist to measure relative humidity, including capacitive, resistive, and resonant gravimetric sensors. For these methods, water must diffuse into a material, which limits the speed of the sensors. Instead, the surface resistance of insulators could be used. But, the resistance cannot be measured using direct measurement techniques because of the high surface resistance (1015 – 1020 Ω/□ for silicon dioxide).

In our sensor, a resonator is used to indirectly measure the surface resistance of silicon dioxide.  As relative humidity increases, the surface resistance of the silicon dioxide decreases because the thickness of adsorbed water on the surface increases. This decrease in surface resistance leads to faster charge decay from a capacitor. . An electrically connected resonator converts the charge on the capacitor to a frequency via the electrostatic spring softening term of the resonator. Next, an oscillator and counter are used to measure frequency shift over time. Finally, this time-varying shift in resonant frequency is used to determine the relative humidity of the ambient.

To characterize our sensor, a custom experimental test setup, including environmental chamber and oscillator board, was built. The effect of relative humidity and temperature on the surface resistance and the charge decay characteristic of the resonator were measured. Our sensor has 50 times improvement in the minimal detectible signal over commercial sensors. Additionally, our sensor are faster than the commercial sensors.  Finally, the measured hysteresis of our sensor is <0.25% relative humidity.

Potential design improvements will be discussed including modification of the surface with Atomic Layer Deposition (ALD) films to change the surface resistance by modifying the thickness of the adsorbed water. Additionally, ground rings around the bondpads can  reduce the steady state surface resistance and decrease the drift caused by the transient response of the surface resistance. Finally, potential extensions of our sensor to other quasistatic charge measurements, including dielectric conduction, biological sensors, gas sensors and chemical sensors, will be briefly discussed.

Tuesday, February 21, 2012

Special Seminar: Pamela Bhatti "MEMS-based approaches to overcoming sensory loss in the auditory and vestibular systems"

Special Seminar

MEMS-based Approaches to Overcoming Sensory Loss in the Auditory and Vestibular Systems

Presented by:

Prof. Pamela T. Bhatti
School of Electrical and Computer Engineering, Georgia Institute of Technology

Monday, February 27, 2012
Clark Center Auditorium
4:00 PM

Abstract:
In the BioSystems Interface Laboratory we develop novel sensing and stimulating systems to 
overcome sensory loss. To enhance sound perception with cochlear implants, we have 
developed advanced thin-film intracochlear electrode arrays. Moving to the vestibular system, 
we pursue both an implantable and non-implantable systems. Analogous to a cochlear implant, 
we are developing a vestibular prosthesis to convey head rotation cues to the vestibular system 
through electrical stimulation of vestibular nerve fibers to overcome debilitating bilateral 
vestibular hypofunction. Complementing our work in implantable systems, we have developed 
a head worn angular motion monitoring system to aid patients in completing vestibular 
rehabilitation exercises at home. By utilizing a user-friendly interface to the system we hope to 
facilitate the transfer of patient measures to a clinic between rehabilitation sessions.

Short Bio:
Dr. Pamela Bhatti is an Assistant Professor in the School of Electrical and Computer Engineering
at Georgia Tech in Atlanta, GA. She received a B.S. in Engineering Science (Bioengineering) from
the University of California, Berkeley in 1989, an M.S. in Electrical Engineering from the University
of Washington in 1993, and a Ph.D. in Electrical Engineering from the University of Michigan, Ann
Arbor in 2006 with an emphasis on Micro-electro Mechanical Systems (MEMS). Before completing
her Ph.D., she researched the detection of breast cancer with ultrasound imaging at the University
of Michigan's Department of Radiology (1997-1999). Her industry experience includes embedded 
systems software development at Microware Corporation, Des Moines, IA (1996-1997), local 
operating network applications development and customer support at Motorola 
Semiconductor in Austin, TX (1994-1995), and research and fabrication of controlled-release 
drug delivery systems at Alza Corporation in Palo Alto, CA (1986-1990). Pamela received the 
NSF CAREER Award in 2011. Committed to translating technology to the clinical setting, she is a 
KL2 Scholar with the Atlanta Clinical and Translations Sciences Institute.


REMINDER: Seminar Today - Nathan Klejwa, "Now we need a 5th order aberration-corrected TEM to see what’s gone wrong", Tuesday, February 21, 2012, 4-5pm Allen 101X Auditorium

Hi all,

Please plan on attending this interesting seminar TODAY by Nathan Klejwa from Halcyon Molecular, Inc..

Tuesday, February 21, 2012, 4:00-5:00 
Allen 101X Auditorium

Title:
Now we need a 5th order aberration-corrected TEM to see what's gone wrong

Speaker:
Nathan Klejwa
Project Manager, Halcyon Molecular, Inc., Redwood City, California


Abstract:
Low-cost, widely available DNA sequence data will make medicine an information science, allowing doctors and patients to predict drug reactions, target specific cells, and tailor treatments to individual patients. Current sequencing methods use short read-length data mapped to a genomic reference to detect small-scale genomic variation in the "easy to read" sections of the genome. Structural variations, which occur over large genomic distances, are extremely difficult to detect with these  methods, and are common determinants of phenotypic variation and diseases such as cancer. Halcyon Molecular seeks to use high-resolution electron microscopy to directly read long, contiguous sections of human DNA and create truly de novo genomes. This talk will highlight some of the technical challenges and interesting solutions unique to this highly interdisciplinary approach to DNA sequencing.

Short Bio:
Nathan Klejwa is currently a PhD student at Stanford University and an engineering project manager at Halcyon Molecular, Inc. His research includes rapid prototyping and low-cost processing for reel-to-reel compatible microsystems. This work aims to minimize complex, time-intensive, and expensive fabrication steps and maximize design flexibility, both for academic prototyping and full-scale production. During the past year at Halcyon Molecular, he has overseen efforts in direct DNA manipulation, biological sample preparation, microscopy infrastructure, and microfabrication.


Hope to see you all there,
Jose

--
Jose Padovani
Graduate Student
Electrical Engineering Department
Stanford University
(650) 796-1971

Re: Lab Bins and Lockers!

Hi Mary,

Happy new year.  I am so glad that the lab is open now.  Great job by the team to have many tools functioning when the lab reopened.  As I was covering fro another colleague of mine who had to go on leave of absence, I was unable to help out during the transition.  I will be able to do some work going forward.  Please let me know if you need any help.

I would like to keep the bin I have in the litho area.  Mihir also has lab bins and we would like to retain those under Intermolecular account as we have other users from Intermolecular (Ludwig & Aleta and Xuena).  I will fill out the paperwork when you post the link. 

Regards,

Usha

On Fri, Feb 17, 2012 at 6:03 PM, Mary Tang <mtang@stanford.edu> wrote:
Dear labmembers --

We know this is a subject that is dear to your hearts:  storage bins.  We have had two problems with bin management that we hope to address this year.  First, there never seems to be enough bins.  Actually, with 300 bins in the lab, there should be enough to supply one for every labmember who spends more than even just 5 hours/month in the lab.  The issue has been staying on top with labmembers who are not very active or who have left.  Second (and actually a more serious problem) is that unless a bin subscription is actively canceled or transferred, we may continue to bill expired accounts.  Although it's not a lot of money, it creates some really serious accounting problems.

So, starting this year, we will be requiring each labmember to actively renew their bin or locker subscriptions each month.  It will be a simple online procedure, but you have to verify that you are still using the bin or locker and that you are accepting this charge on your project. Bins and lockers that are not renewed may be reassigned.  And you can transfer your bin assignment to a labmate, if you like.  As before, bin and locker assignments are subject to availability -- and active lab use by the individual labmember, as defined by equipment enabling.

We will begin assigning lab bins on Wednesday, Feb. 22.  In general, priority will be given to labmembers who capped in Oct/Nov before shutdown; those who are actively using the lab right now (i.e., enabling tools for hours, as opposed to minutes); and those wonderful souls who helped with the lab shutdown and startup.

In the meantime, if you are working in the lab this weekend, you may bring your personal items into the lab and place them temporarily in one empty bin, provided you leave a note clearly showing your Coral ID and contact info.  Be aware, though, that bins will be assigned randomly so that you should move/remove your belongings by Wednesday when assignments begin.

Thanks for your patience and cooperation as we work on this new system --

Your SNF staff

Take a spin with me HEADWAY training cancelled today

Good morning
Take a spin with me, HEADWAY Training cancelled today
Will reschedule
James Conway

Sunday, February 19, 2012

EE Ph.D. Oral Examination: Jae-Woong Jeong, Feb. 27 at 3:00 pm, CIS-X Auditorium

Stanford University Ph.D. Oral Examination – Department of Electrical Engineering

 

Title:

Design of Optical Microsystems:

Applications in Biomedical Imaging and Optical Communication

 

Speaker: Jae-Woong Jeong

Advisor: Professor Olav Solgaard

 

Date: Monday, February 27, 2012

Time: 3:00 pm (refreshments at 2:45 pm)

Location: Allen-X Auditorium (formerly CIS-X Auditorium) - Room 101

 

Abstract:

 

Scaling of optical systems can open up new opportunities for various applications by enabling what would not be possible on a larger scale. Such miniaturized optical systems can be achieved through optical MEMS (Micro-electro-mechanical systems) technology. This technology not only enables optical devices with high performance and high functionality, but also allows miniaturization, integration, and batch fabrication of optical systems, making them portable, reliable, and cost-effective. In this talk, I will present two novel optical microsystems for applications in biomedical imaging and optical communication.

 

    In the first part of my talk, I will introduce the 3-D MEMS scanning system for a miniature dual-axis confocal (DAC) microendoscope, which is an emerging biomedical imaging modality with high resolution, good tissue penetration, large field of view, and the ability to provide both reflectance and fluorescence contrast images. A pair of MEMS scanners (2-D lateral and 1-D vertical MEMS scanners) that are designed to achieve 3-D scanning in an endoscope-compatible imaging probe will be presented. In addition, front-side processing of the scanners that enables not only simple and cost-effective fabrication but also compact and robust structures will be described. Co-operation of a 2-D lateral scanner and a 1-D vertical scanner enables fast 3-D microscopy over a volume that measures 340μm X 236μm X 286μm. I will describe the principle of the all-MEMS-based 3-D scanning DAC microscopy that gives the functionality of OCT to a confocal microscope by producing real-time imaging along the axial direction of the microscope.


    In the second part of my talk, I will describe the design, fabrication, and characterization of a multi-functional tunable optical filter, which is a key element for dynamic wavelength provisioning in reconfigurable optical networks and communication systems. This filter can control both the center wavelength and the passband independently and continuously, using a MEMS spatial light modulator (SLM) that is implemented with gold-coated mirrors microassembled on a MEMS platform. The design of SLM with large displacement bi-directional combdrive actuators will be demonstrated. Also, MEMS platform technology that enables a compact chip size with large apertures and high-quality optical mirrors will be presented. To verify the performance of the filter, it has been tested as an amplified spontaneous emission (ASE) noise rejection filter in a 10Gb/s optical communication system. I will discuss the filtering performance in the optical system in terms of bit error rate improvement.


Saturday, February 18, 2012

PhD Defense: A Vacuum Encapsulated Resonator for Humidity Measurement - Wed. 2:15pm Allen 101x

University PhD Dissertation Defense

A Vacuum Encapsulated Resonator for Humidity Measurement

Robert Hennessy
Department of Electrical Engineering
Advisor: Prof. Roger T. Howe

Wednesday, February 22, 2012
2:15 pm (refreshments at  2 pm)
Paul G. Allen Auditorium (CIS-X 101)

http://cis.stanford.edu/directions/


Relative humidity sensing is important in many applications including home appliances, semiconductor manufacturing, air conditioning, medical, automotive and meteorological. Various technologies exist to measure relative humidity, including capacitive, resistive, and resonant gravimetric sensors. For these methods, water must diffuse into a material, which limits the speed of the sensors. Instead, the surface resistance of insulators could be used. But, the resistance cannot be measured using direct measurement techniques because of the high surface resistance (1015 – 1020 Ω/□ for silicon dioxide).

In our sensor, a resonator is used to indirectly measure the surface resistance of silicon dioxide.  As relative humidity increases, the surface resistance of the silicon dioxide decreases because the thickness of adsorbed water on the surface increases. This decrease in surface resistance leads to faster charge decay from a capacitor. . An electrically connected resonator converts the charge on the capacitor to a frequency via the electrostatic spring softening term of the resonator. Next, an oscillator and counter are used to measure frequency shift over time. Finally, this time-varying shift in resonant frequency is used to determine the relative humidity of the ambient.

To characterize our sensor, a custom experimental test setup, including environmental chamber and oscillator board, was built. The effect of relative humidity and temperature on the surface resistance and the charge decay characteristic of the resonator were measured. Our sensor has 50 times improvement in the minimal detectible signal over commercial sensors. Additionally, our sensor are faster than the commercial sensors.  Finally, the measured hysteresis of our sensor is <0.25% relative humidity.

Potential design improvements will be discussed including modification of the surface with Atomic Layer Deposition (ALD) films to change the surface resistance by modifying the thickness of the adsorbed water. Additionally, ground rings around the bondpads can  reduce the steady state surface resistance and decrease the drift caused by the transient response of the surface resistance. Finally, potential extensions of our sensor to other quasistatic charge measurements, including dielectric conduction, biological sensors, gas sensors and chemical sensors, will be briefly discussed.

Friday, February 17, 2012

thanks to the 23 entrants

Dear Labmembers,

The competition is closed -- we've received many designs for the new
logo from 23 contributors. The winner will be announced sometime next week.

Thanks,
Roger Howe

Lab Bins and Lockers!

Dear labmembers --

We know this is a subject that is dear to your hearts: storage bins.
We have had two problems with bin management that we hope to address
this year. First, there never seems to be enough bins. Actually, with
300 bins in the lab, there should be enough to supply one for every
labmember who spends more than even just 5 hours/month in the lab. The
issue has been staying on top with labmembers who are not very active or
who have left. Second (and actually a more serious problem) is that
unless a bin subscription is actively canceled or transferred, we may
continue to bill expired accounts. Although it's not a lot of money, it
creates some really serious accounting problems.

So, starting this year, we will be requiring each labmember to actively
renew their bin or locker subscriptions each month. It will be a simple
online procedure, but you have to verify that you are still using the
bin or locker and that you are accepting this charge on your project.
Bins and lockers that are not renewed may be reassigned. And you can
transfer your bin assignment to a labmate, if you like. As before, bin
and locker assignments are subject to availability -- and active lab use
by the individual labmember, as defined by equipment enabling.

We will begin assigning lab bins on Wednesday, Feb. 22. In general,
priority will be given to labmembers who capped in Oct/Nov before
shutdown; those who are actively using the lab right now (i.e., enabling
tools for hours, as opposed to minutes); and those wonderful souls who
helped with the lab shutdown and startup.

In the meantime, if you are working in the lab this weekend, you may
bring your personal items into the lab and place them temporarily in one
empty bin, provided you leave a note clearly showing your Coral ID and
contact info. Be aware, though, that bins will be assigned randomly so
that you should move/remove your belongings by Wednesday when
assignments begin.

Thanks for your patience and cooperation as we work on this new system --

Your SNF staff

SNF logo competition: only 8 hours to go!!

Dear Labmembers and friends of the SNF,

Just a reminder that today at 5:00 pm is the deadline. We have had many
entries, but the winning one may be still waiting to be submitted ... or
still not conceived!

Thanks,
Roger

Thursday, February 16, 2012

RAITH information and applications meeting

Friday February 17th, 2012 in Packard 242 (2nd Floor) 9:30 to 11:00 AM

Raith Applications Scientist Joe Klingfus will be available tomorrow to answer any questions you may have about RAITH lithography and measurement systems, or to discuss any aspect of the RAITH Nanosuite Version 6 and the hardware we have recently upgraded to on our RAITH 150 system here at Stanford.

This meeting completes a full week of topics in EBL / IBL Advanced Lithography methods on the RAITH tools including the new Fixed Beam Moving Stage and the Modulated Beam Moving Stage module that were donated to us by RAITH USA Inc.  This is a limited term agreement covering the next 24 months and I hope we can develop some new applications for this methodology in collaboration with RAITH USA Inc.

For those persons whom missed presentations during the Advanced Lithography Workshop, and the FBMS training classes today, this will be your last opportunity to get your questions answered and discuss with him possible applications on this package in person during this visit.

Hope to see you tomorrow morning.

James Conway

Brief description pardon the poor text conversion in translation. - JWC

The FBMS lithography module comprises design, control, and exposure of structures In a fixed-beam-moving-
stage mode. This allows excellent precision and flexibility in exposing thin, but extended lines
or paths known from integrated optics structures (i.e. waveguides) or in x-ray optics patterns with no
stitch field boundaries.

Exposures can be realized with a true stationary beam or using a programmable high speed beam
shape continuously formed by the pattern generator during controlled stage movement.

This operation allows fabrication of well-defined line width without having the need to rely on a defocused beam.
The patterns to be exposed are fully integrated into an extended GDSII database and editor.

Standard beam scanning and path control exposure sequences can be mixed and executed directly from a single GDS ll file.
The FBMS editing functionality allows to define lines of  flexible geometry and to prepare it for direct exposure in FBMS control mode.
In FBMS exposure mode the stage motion is controlled via intelligent stage electronics based on high performance OSF architecture,

System features:
 - writes smooth continuous patterns over large distances with no stitching errors
- capable of curved paths and standard scanning beam pattern definitions
- dedicated curved path editor and conversion functions included.
- stage follows curved paths at constant speed under laser control with beam feedback loop
- spot mode and programmable beam shape exposure for flexible line width and patterning control
- combined FBMS and vector scan exposures In one run
- standard free, intrinsic calibration mode for multiple scan field sizes
- FBMS exposure control fully integrated in Raith multi user software interface

Stanford CPN Nanoprobes Workshop, May 18, 2012

Dear SNF labmembers (feel free to forward to others),

You are cordially invited to:
Stanford University's Center for Probing the Nanoscale (CPN) 8th Annual Workshop,
May 18, 2012 - (Students and Postdocs are FREE)

Registration is open

Speakers:

Stuart Lindsay, Arizona State University 

Sarah Tolbert, University of California, Los Angeles 

Felice Frankel, Harvard University 

Katherine Aidala, Mount Holyoke College 

Abhay Pasupathy, Columbia University

Ania Bleszynski Jayich, University of California, Santa Barbara 

Michael Flatté, University of Iowa

James Hone, Columbia University


Best wishes,
David
-----------------------------------------------------------------
David Goldhaber-Gordon                            goldhaber-gordon@stanford.edu
Associate Professor of Physics                  davidg@post.harvard.edu
and Director,                                                  (permanent forwarding)
Center for Probing the Nanoscale                             
Stanford University                                    www.stanford.edu/group/cpn/
(650) 725-2047 (lab) (650) 724-3709 (office)

Address for letters or packages:                      Administrative Associate:
David Goldhaber-Gordon                                 Roberta Edwards
Geballe Laboratory for Advanced Materials       McCullough, Rm. 338
McCullough Building, Room 346                      Phone: (650) 723-8028
476 Lomita Mall                                             Fax: (650) 724-3681
Stanford, CA 94305-4045                                email: redward@stanford.edu

Wednesday, February 15, 2012

Comment p5000etch SNF 2012-02-15 17:26:31: Robot extension problem

The extension cable is bad, problem is intermittent. Need
to change interface extension ribbon cable..

Plenty of food for you at Allen X 101

Help yourself
Plenty of food for all
James

We're open for business!

Dear labmembers --

Thanks for your patience -- at long last, we are open again! However,
please do be aware that many tools remain down and/or untested. We are
by no means back to normal operations. Make sure to check Coral for
specific tool status.

The second question after "when will you open" is "when get I get a
bin"? Rest assured that we are working on revamping the system, but are
making bringing tools back up a priority. Please expect to see bin
assignment rules soon. Just a heads-up -- there will be a priority
assignment policy based on previous recent active lab use (if you've
capped before shutdown, for example) -- and those who have helped with
the lab startup will get their choice of storage options (and if you are
interested in this limited offer, please contact a staff member.)

Hope to see you in the lab!

Your SNF staff


--
Mary X. Tang, Ph.D.
Stanford Nanofabrication Facility
Paul G. Allen Room 136, Mail Code 4070
Stanford, CA 94305
(650)723-9980
mtang@stanford.edu
http://snf.stanford.edu

White light update

Hello all,

Diffusion bench up
New SRD installed and tested upper  unit is up, we are not up for 3' and 6" yet.

wbnonmetal, wbgen, wbsilicide, wbsolven, wbgaas are all up.
wbmetal  Down
Wbnitride  down

Most  characterization tools are up except
stress tester and alphastep  are still down.

white light team





litho update

Hello all,

welcome back
Here is a quick up date, please note the issues and problems on coral
that will be more helpful to all of us.

I will post a copy of the report by the lab entrance.

Litho team

Tuesday, February 14, 2012

Problem p5000etch SNF 2012-02-14 18:22:49: CH A and Ch C offline

No BCl3 or Cl until further notice.

REMINDER Seminar: Adam de la Zerda, "Imaging Cancer Biomolecules using Light, Sound and Bio-orthogonal Chemistry", TODAY 4PM Allen 101X

Hi all,

Please plan on attending this interesting seminar TODAY by Adam de la Zerda on dynamics of cancer-specific biomolecules using molecular imaging technologies.

Who: Adam de la Zerda, PhD 
When: Tuesday, Feb 14 4:00-5:00 pm
Where: Allen 101X Auditorium

Title: Imaging Cancer Biomolecules using Light, Sound and Bio-orthogonal Chemistry

Abstract:
Many cancer-specific biomolecules are dynamic in space, time and local environments. Hence,
in order to truly understand their role in cancer progression, it is important to visualize them in
living subjects – their most natural environment. In this talk, we introduce a number of new
molecular imaging technologies as well as new chemistry that allows interrogation of many
cancer biomarkers for the first time. We first introduce photoacoustic molecular imaging, a
technology where short light pulses are converted into ultrasound waves by a contrast molecule.
By measuring the ultrasound waves emanating from the body, one can create a detailed 3D
image of contrast molecules that target cancer. Second we will introduce our current work on a
novel chemistry approach for targeting cancer-specific glycans (sugars). Altered glycan patterns
are a hallmark of cancer but are very difficult to image. We will present a novel chemistry
method for labeling cell-surface glycans based on specific chemical reactions that are orthogonal
to all other biological processes, hence, allowing very specific and sensitive detection.

Profile:
Dr. Adam de la Zerda will be joining the faculty of Structural Biology at Stanford Medical School in September
2012 as an Assistant Professor. In 2011 Dr. de la Zerda finished his PhD in Electrical Engineering at Stanford
University, and is currently a postdoctoral fellow in Chemistry at UC Berkeley. He is working on the development
of new molecular imaging technologies to visualize and interrogate various biomolecules in cancer. Dr. de la Zerda
has received numerous awards for his research including the Damon Runyon Cancer Research Foundation
Fellowship (2011), Era of Hope Distinguished Predoctoral Award (2011), Best Poster Presentation at SPIE
Photonics West (2009), the Young Investigator Award at the World Molecular Imaging Congress (2008), the
Department of Defense Breast Cancer Research Program Predoctoral Award (2008), and the Bio-X Graduate
Student Fellowship (2008). He published over 13 papers in leading journals including Nature Nanotechnology,
Nature Medicine, Nano Letters, and PNAS, some of which received significant press coverage from Forbes
Magazine, US News and The Washington Post. He holds a number of patents and is the co-founder of a medical
imaging device company, OcuBell Inc. He studied Computer Engineering at the Technion – Israel Institute of
Technology where he graduated with a B.Sc. Summa Cum Laude .

Hope to see you all there.

Jose

--
Jose Padovani
Graduate Student
Electrical Engineering Department
Stanford University
(650) 796-1971

Lab reopening: Wed. Feb. 15, 10 am

Dear labmembers --

We are extremely pleased to be able to confirm that the lab will reopen
tomorrow, Wed., Feb. 15, at 10 am. The last of the building wide
shutdowns took place successfully yesterday. In addition, the acid
waste neutralization system was fully tested. There are a couple of
local facilities shutdowns today and in coming weeks, but these will not
be showstoppers.

Please be aware that this shutdown was considerably more extensive than
our regular annual routine. Many tools will remain down or untested.
Please check Coral for status of individual tools.

Your SNF Staff

Monday, February 13, 2012

PhD Defense Announcement: Joey Doll

University PhD Dissertation Defense

MEMS force probes for mechanobiology at the microsecond scale                                                                                                                                                                                                                                                                                                                        

Joey Doll
Department of Mechanical Engineering
Advisor: Prof. Beth L. Pruitt

Wednesday, March 7, 2012
9:00 am (refreshments at 8:45 am)
Paul G. Allen Auditorium (CIS-X 101)

Life is built upon mechanical forces, which play a central role in everything from cell division to embryonic development. Rather than acting as passive mechanical elements, cells and molecules sense and actively respond to mechanical loads. One example of cellular force sensing is mechanotransduction, the conversion of mechanical energy into an electrical signal, which underlies our senses of hearing, touch and balance. For example, the cochlear hair cells in your inner ear are exquisitely sensitive and fast, capable of sensing piconewton-scale forces at the microsecond-time scale. But in order to understand such fast mechanotransduction processes we must first be able to apply and measure small, fast forces. A variety of instruments have been developed for the precise measurement of biological forces and displacements in the past 25 years. The most commonly used techniques are atomic force microscopy, magnetic tweezers, and optical tweezers. Each provides a tradeoff in force, displacement and time resolution, but none of them are capable of applying and detecting forces fast enough for the study of cochlear hair cells.

In order to address this technological gap we have developed microfabricated force probes for the application and measurement of forces at the piconewton- and microsecond-scale. In order to simultaneously achieve a high resonant frequency (10-200 kHz in water), low stiffness (0.3-30 mN/m) and low minimum detectable force (10-100 pN), the probes are roughly 300 nm thick, 1 micron wide and 30-200 microns long. Force applied to the cantilever tip is transduced into a voltage by a piezoresistive silicon strain gauge that is embedded in the beam. Actuation is accomplished through a piezoelectric aluminum nitride film or a resistively heated aluminum film to enable high-speed operation without spurious resonant modes. The probes are mass produced on silicon wafers using conventional batch fabrication techniques, and their dimensions are individually adjusted lithographically to accommodate a wide range of desired force and time resolutions. Optics are not required for sensing or actuation so the probes can be integrated with any standard upright up inverted microscope. 

This talk will begin with a discussion of the mechanical, electrical and thermal design of the force probes. Numerical design optimization is utilized to satisfy the numerous design and performance constraints. Next, I will present the seven- and nine-mask fabrication processes used to manufacture the thermally and piezoelectrically actuated probes. The sensing and actuation performance of the probes will be individually addressed before discussing their integration, particularly crosstalk compensation. I will conclude by presenting preliminary data on the measurement of mammalian hair cell kinetics using the piezoelectrically actuated probes.